Journal
AGING AND DISEASE
Volume 11, Issue 2, Pages 405-418Publisher
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2019.0521
Keywords
physical frailty; cognitive decline; biology; cognitive frailty
Categories
Funding
- National Natural Science Foundation of China [81600927]
- National Key R&D Program of China [2018YFC2002101, 2018YFC 1312001, 2017YFC0840105]
- Beijing Municipal Science & Technology Commission [Z171100000117013]
- Beijing Municipal Administration of Hospitals' Mission Plan [SML20150803]
- Milstein Medical Asian American Partnership Foundation Project Award in Geriatrics
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Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidence linking physical frailty to cognitive decline, a complete understanding of the underpinning biological basis of the two disorders remains fragmented. This narrative review discusses insights into the potential roles of chronic inflammation, impaired hypothalamic-pituitary axis stress response, imbalanced energy metabolism, mitochondrial dysfunction, oxidative stress, and neuroendocrine dysfunction linking physical frailty with cognitive decline. We highlight the importance of easier identification of strategic approaches delaying the progression and onset of physical frailty and cognitive decline as well as preventing disability in the older population.
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