Journal
TRENDS IN CANCER
Volume 6, Issue 4, Pages 319-336Publisher
CELL PRESS
DOI: 10.1016/j.trecan.2020.01.012
Keywords
-
Categories
Funding
- National Key R&D Program of China [2016YFA0502204, 2017YFA0504304]
- National Natural Science Foundation of China [81772960, 81903082]
- Fundamental Research Funds for the Central Universities [2018SCUH0018]
- Sichuan Science and Technology Program [2019JDTD0013]
- 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University [ZYJC18030]
- National Postdoctoral Program for Innovative Talents of China [BX20190225]
Ask authors/readers for more resources
Circular RNA (circRNA) is a class of single-stranded molecules with tissue/development-specific expression patterns. Unlike linear RNA, circRNA forms a covalently closed loop produced from 'back-splicing' of primary transcripts, conferring on them inherent resistance to exonucleolytic RNA decay. Increasing evidence demonstrates that many circRNAs exert important biological functions by acting as miRNA inhibitors ('sponges'), protein 'decoys', or by encoding small peptides. Importantly, circRNAs are aberrantly expressed in cancer and play indispensable oncogenic or tumor suppressive roles during tumor development and progression. In this review, we summarize the biogenesis, turnover, and involvements of circRNAs in cancer and also discuss their potential as diagnostic biomarkers or therapeutic targets.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available