Journal
TOXICS
Volume 8, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/toxics8010019
Keywords
gut microbiome; environment; chemical toxicity
Categories
Funding
- University of Georgia
- University of North Carolina at Chapel Hill
- NIH/NIEHS [R01ES024950]
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The human gut microbiome can be easily disturbed upon exposure to a range of toxic environmental agents. Environmentally induced perturbation in the gut microbiome is strongly associated with human disease risk. Functional gut microbiome alterations that may adversely influence human health is an increasingly appreciated mechanism by which environmental chemicals exert their toxic effects. In this review, we define the functional damage driven by environmental exposure in the gut microbiome as gut microbiome toxicity. The establishment of gut microbiome toxicity links the toxic effects of various environmental agents and microbiota-associated diseases, calling for more comprehensive toxicity evaluation with extended consideration of gut microbiome toxicity.
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