Hypervalent iodine-catalyzed conjugate addition with sulfonamides

A hypervalent iodine-catalyzed conjugate addition with a sulfonamide nucleophile is described here. This reaction utilizes catalytic amounts of iodoarene and oxidant for the generation of the active hypervalent iodine catalyst. Activation of the enone substrate by the hypervalent iodine catalyst enables the nitrogen nucleophile addition that eventually forms a useful beta-aminocarbonyl product. This hypervalent iodine-catalyzed Aza-Michael reaction represents an interesting alternative to existing conjugate addition protocols. [GRAPHICS] .