Journal
BIOORGANIC CHEMISTRY
Volume 51, Issue -, Pages 16-23Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2013.09.001
Keywords
Antibacterial; Antifungal; Antimalarial
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A series of eight 4'-[4-(3-substituted phenyl-acryloyl)-piprazin-1-ylmethyl]-biphenyl-2-carbonitrile were synthesized using 4'-Bromomethyl-biphenyl-2-carbonitrile and 4-Acetyl piprazine as a starting material. Furthermore, there has been some additional work done investigating effects of these derivatives on biological activities on bacterial, fungal and malarial strain. Synthesized compounds were characterized using FTIR, H-1 NMR and C-13 NMR spectrometry. These compounds shows good antimalarial, antibacterial and antifungal activity. In fact some compounds are more potent than standard drug quinine and Ampicillin some are with comparable activity with Ampicillin and quinine. (C) 2013 Elsevier Inc. All rights reserved.
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