Journal
BIOORGANIC CHEMISTRY
Volume 40, Issue -, Pages 108-113Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2011.09.006
Keywords
Cationic porphyrin; Chelator; Antitumor agent; Human neuroendocrine tumor cells; Medullary thyroid carcinoma cell lines; Small intestinal carcinoma cell lines
Funding
- Austrian Science Fund FWF [P-18384]
- Stadt Graz Wissenschaft
- Franz Lanyar Foundation
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In this study, a completely water soluble tri-cationic porphyrin-EDTA conjugate was synthesized. We present data demonstrating the tumoristatic effects of the novel fully water soluble cationic porphyrin TMPy(3)PhenEDTA-P-Cl-4 in the dark, in the medullary thyroid carcinoma cell lines MTC-SK and SHER-I and weaker effects in the small intestinal neuroendocrine tumor cell line KRJ-I. In addition, cytotoxic effects were also studied in normal human fibroblasts that represent normal tissue and the results are compared to the tumor cell lines. (C) 2011 Elsevier Inc. All rights reserved.
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