Journal
BIOORGANIC CHEMISTRY
Volume 39, Issue 1-3, Pages 88-93Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2010.12.002
Keywords
GPI anchor; Glycosylations; PNH disease
Funding
- Istituto Toscano Tumori (ITT), Florence, Italy
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The biological role of GPI anchors is of paramount importance: however, we are still far from fully understanding the structure-function relationship of these molecules. One major limiting factor has been the tiny quantities available from natural sources: obtaining homogeneous and well-defined GPI structures by synthesis, is both a challenge and an attractive goal. We report here the convergent synthesis of the essential core of the human GPI anchor 1, exploiting a common precursor to obtain the trisaccharidic donor 2 and a novel protecting groups sequence. The final product, prepared for the first time, is biologically active. (C) 2011 Published by Elsevier Inc.
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