Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 28, Issue 21, Pages 3472-3476Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2018.09.019
Keywords
Respiratory syndrome; Coronavirus; 3CL protease; 1,2,3-triazole; Biological evaluation
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Funding
- Katholieke Universiteit Leuven (KU Leuven) [C32/15/033, ISPLA2/15/03]
- Secretaria de Ciencia y Tecnica of the Universidad Nacional de Cordoba (SECYT-UNC)
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
- Agencia Nacional de Promocion Cientifica y Tecnica (ANPCyT)
- NVIDIA Corporation
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Synthesis and biological evaluation of a novel library of fused 1,2,3-triazole derivatives are described. The in-house developed multicomponent reaction based on commercially available starting materials was applied and broad biological screening against various viruses was performed, showing promising antiviral properties for compounds 14d, 14n, 14q, 18f and 18i against human coronavirus 229E. Further in silico studies identified the key molecular interactions between those compounds and the 3-chymotrypsin-like protease, which is essential to the intracellular replication of the virus, supporting the hypothesis that the protease is the target molecule of the potential antiviral derivatives.
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