Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 24, Issue 2, Pages 473-475Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.12.037
Keywords
Kelsoane-type sesquiterpenes; Nephthea erecta; Quantum chemical calculations (QCC); Cytotoxicity
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Funding
- National Science Council [NSC102-2113-M-390-001, NSC102-2320-B-110-003-MY3]
- NSYSUKMU Joint Project [NSYSUKMU 2013-P018]
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Two new kelsoane-type sesquiterpenes, namely kelsoenethiol (1) and dikelsoenyl ether (2), were obtained from the Formosan soft coral Nephthea erecta. Their structures were elucidated through extensive spectroscopic analyses, ESI orbitrap mass and quantum chemical calculations (QCC). The cytotoxicity against A-459 (human lung carcinoma), P-388 (mouse lymphocytic leukemia), and HT-29 (human colon adenocarcinoma) cancer cell lines of 1 and 2 was evaluated in vitro. Compound 1 showed cytotoxicity against P-388 and HT-29 cells with ED50s of 1.3 and 1.8 mu g/mL, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
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