Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 24, Issue 2, Pages 454-457Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.12.049
Keywords
Lapachol; In vitro growth inhibition; Cancer; 1,4-Naphthoquinones
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Funding
- Universita 'Gabriele d'Annunzio' of Chieti-Pescara
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A series of 17 selected natural and semisynthetic 1,4-naphthoquinones were synthesized, and their growth inhibitory activity was evaluated in vitro. The compounds were tested on six human cancer cell lines using the MTT colorimetric assay. The data revealed that of the chemicals under study only lapachol, its acetate and 3-geranyllawsone displayed the highest activity, recording mean IC50 values ranging from 15 to 22 mu M. (C) 2013 Elsevier Ltd. All rights reserved.
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