Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 24, Issue 6, Pages 1562-1564Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.01.073
Keywords
Sinularia gyrosa; Norcembranoid; Cytotoxicities; Anti-HCMV (human cytomegalovirus); endonuclease activities; Antibacterial activities; P-388 (mouse lymphocytic leukemia)
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Funding
- National Science Council [NSC102-2113-M-390-001, NSC102-2320-B-110-003-MY3]
- NSYSUKMU Joint Project [NSYSUKMU 2013-P018]
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Chemical investigations on the acetone extract of the Formosan soft coral Sinularia gyrosa have obtained a novel C-4 norcembranoid possessing an unprecedented tricyclo[9.3.0.0(3,8)] tetradecane skeleton, namely sinugyrosanolide A. The NMR spectroscopic data of the novel norcembranoid were completely assigned by using a combination of 2D NMR experiments including H-1-H-1 COSY, HSQC, HMBC, and NOESY. The cytotoxicities, anti-HCMV (human cytomegalovirus) endonuclease activities and antibacterial activities were evaluated in vitro. It showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with an EC50 of 11.8 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
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