Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 24, Issue 7, Pages 1851-1855Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.02.003
Keywords
Limonin derivatives; Solubility; Analgesic activity; Anti-inflammatory activity
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Funding
- National Undergraduate Training Programs for Innovation and Entrepreneurship of China
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A novel series of water-soluble derivatives of limonin were synthesized by introducing various tertiary amines onto the C (7)-position of limonin. Ten target compounds were characterized and screened for their anti-inflammatory and analgesic activity in vivo. Compound 3c exhibited the strongest analgesic and anti-inflammatory activity among the limonin and its derivatives tested; its analgesic activity is more potent than that of aspirin and its anti-inflammatory activity is stronger than that of naproxen. (c) 2014 Elsevier Ltd. All rights reserved.
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