Journal
CROHNS & COLITIS 360
Volume 2, Issue 1, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/crocol/otz053
Keywords
adverse psychiatric events; meta-analysis; randomized controlled trials; biologic therapy
Categories
Funding
- Canadian Institutes of Health Research (CIHR)
- Crohn's and Colitis Canada
- Manitoba Research Chair from Research Manitoba
- Bingham Chair in Gastroenterology
- Waugh Family Chair in Multiple Sclerosis
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We conducted a systematic review and a fixed-effects meta-analysis to determine whether incident adverse psychiatric events (APE) including depression, anxiety, psychosis, or suicide were associated with biologic therapy in IBD. Six randomized controlled trials and a cohort study met criteria, reporting an incidence of APE in 4,882 patients. The risk difference per 100 person-months of any APE with a biologic medication was 0.01 (95% confidence interval = 0.00-0.02). There was insufficient evidence available in randomized controlled trials to conclude that biologic therapy in IBD is associated with an increased incidence of APE.
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