Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 24, Issue 7, Pages 1724-1729Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.02.042
Keywords
Amides; Polyether ionophores; Anticancer properties; Antibacterial activity; Natural compounds
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Funding
- Polish National Science Centre (NCN) [2011/03/D/ST5/05884]
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A series of 11 novel amides of salinomycin were synthesized for the first time. All the obtained compounds were found to show potent antiproliferative activity against human cancer cell lines including the drug-resistant cancer cells. Four new salinomycin derivatives revealed good antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus epidermidis (MRSE). (c) 2014 Elsevier Ltd. All rights reserved.
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