Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 24, Issue 21, Pages 4939-4942Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.09.040
Keywords
Actinomycetes; Micrococcus sp.; Spheciospongia vagabunda; Xanthone; Antimicrobial activity
Categories
Funding
- Egyptian Ministry of Higher Education
- [DFG-SFB630-TP A5]
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Microluside A [4 (19-para-hydroxy benzoyloxy-O-beta-D-cellobiosyl), 5 (30-para-hydroxy benzoyloxy-O-beta-D-glucopyranosyl) xanthone (1)] is a unique O-glycosylated disubstituted xanthone isolated from the broth culture of Micrococcus sp. EG45 cultivated from the Red Sea sponge Spheciospongia vagabunda. The structure of microluside A was determined by 1D- and 2D-NMR techniques as well as high resolution tandem mass spectrometry. The antimicrobial activity evaluation showed that 1 exhibited antibacterial potential against Enterococcus faecalis JH212 and Staphylococcus aureus NCTC 8325 with MIC values of 10 and 13 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.
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