Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 24, Issue 15, Pages 3389-3391Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.05.083
Keywords
Xylarianaphthol-1; Dinaphthofuran; Marine natural product; Structure elucidation; Total synthesis; p21 promoter activator
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [22241053, 23102005]
- Grants-in-Aid for Scientific Research [23102005, 22241053, 26242074] Funding Source: KAKEN
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Xylarianaphthol-1, a novel dinaphthofuran derivative, was isolated from a marine sponge-derived fungus of order Xylariales on the guidance of a bioassay using the transfected human osteosarcoma MG63 cells (MG63(luc+)). The chemical structure of xylarianaphthol-1 was determined from the H-1 and C-13 NMR analysis and was further confirmed by the total synthesis. Xylarianaphthol-1 activated p21 promoter stably transfected in MG63 cells dose-dependently. Expression of p21 protein in the wild-type MG63 cells was also increased by xylarianaphthol-1 treatment. (C) 2014 Elsevier Ltd. All rights reserved.
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