D-dimer as a thrombus biomarker for predicting 2-year mortality after percutaneous coronary intervention

Background: D-dimer has predictive value for mortality in some diseases. This study aimed to evaluate the correlation between D-dimer and mortality in patients undergoing percutaneous coronary intervention (PCI). Methods: We examined 10,724 consecutive patients who underwent PCI between January 2013 and December 2013. The primary endpoint was all-cause mortality, and the secondary endpoint was cardiac mortality. Patients were divided according to the median D-dimer level of 0.28 mu g/ml. Multivariable model were including age, sex, and risk factors after stepwise selection. Results: After a 2-year follow up, 8565 patients with D-dimer data were analyzed. There were 116 (1.35%) all-cause deaths and 64 (0.75%) cardiac deaths. D-dimer levels were significantly higher in the all-cause mortality group [0.42 (0.29, 0.68) mu g/ml] and cardiac mortality group [0.48 (0.30, 0.81) mu g/ml] than in the survival group [0.28 (0.20, 0.41) mu g/ml] (both p < 0.001). Multivariate-adjusted Cox hazard analysis showed that high D-dimer levels (> 0.28 mu g/ml) were significantly associated with all-cause mortality in the total population [hazard ratio (HR): 2.35, 95% confidence interval (CI): 1.44-3.84, p = 0.001], acute coronary syndrome (ACS) subgroup (HR: 1.91, 95% CI: 1.08-3.38, p = 0.027), and stable coronary artery disease (SCAD) subgroup (HR: 3.82, 95% CI: 1.45-10.10, p = 0.007). High D-dimer levels were significantly associated with cardiac mortality in the total population (HR: 3.44, 95% CI: 1.61-7.36, p = 0.001) and the ACS subgroup (HR: 3.33, 95% CI: 1.38-8.03, p = 0.007), but not in the SCAD subgroup (HR: 3.68, 95% CI: 0.80-16.91, p = 0.094). Conclusions: D-dimer levels are independently associated with 2-year all-cause mortality and cardiac mortality in patients undergoing PCI.