Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 24, Issue 13, Pages 2815-2819Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.04.111
Keywords
Antiproliferative; Pancreatic cancer; Analogue synthesis; Natural products; Organoiron chemistry
Categories
Funding
- HEFCE Higher Education Innovation Fund
- University of Bath RDSO
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We report the synthesis and biological evaluation of three analogues of the natural product (+)-grandifloracin (+)-1. All three analogues exhibit enhanced antiproliferative activity against PANC-1 and HT-29 cells compared to the natural product. The retention of activity in an analogue lacking the enone functional group, 9, implies this structural element is not an essential part of the (+)-grandifloracin pharmacophore. (C) 2014 The Authors. Published by Elsevier Ltd.
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