Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 24, Issue 17, Pages 4095-4098Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.07.066
Keywords
Phorbas sp.; Phorbaketals; Cytotoxicity
Categories
Funding
- Marine Biotechnology Program
- Ministry of Oceans and Fisheries, Korea
- Suncheon Research Center for Natural Medicines
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Three new sesterterpenoids, phorbaketals L-N (1-3), were isolated from a marine sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas cancer cells (IC50 = 11.4 mu M). (C) 2014 Elsevier Ltd. All rights reserved.
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