Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 23, Issue 17, Pages 4801-4805Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.06.098
Keywords
Polygonum multiflorum; Hair growth; Dermal papilla cells (DPCs); Hair-fiber length
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Funding
- Priority Research Center Program through the National Research Foundation of Korea (NRF) [2009-0093815]
- Ministry of Education, Science and Technology, Republic of Korea
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Two new compounds, gallic acid ester of torachrysone-8-O-beta-D-glucoside (1) and (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-xyloside (4), along with eight known compounds (2, 3, 5-10) were isolated from a 70% ethanol extract of Polygonum multiflorum roots. The structures were determined by H-1 and C-13 NMR, HMQC, and HMBC spectrometry. Extracts of P. multiflorum have been reported to promote hair growth in vivo. This study was carried out to evaluate the effects of isolated compounds from P. multiflorum on promoting hair growth using dermal papilla cells (DPCs), which play an important role in hair growth. When DPCs were treated with compounds (1-10) from P. multiflorum, compounds 1, 2, 3, 6, and 10 increased the proliferation of DPCs compared with the control. Specifically, compound 2 (10 and 20 mu M) induced a greater increase in the proliferation of DPCs than minoxidil (10 mu M). Additionally, treatment of vibrissa follicles with compound 2 for 21 days increased hair-fiber length significantly. On the basis of this result, further investigation and optimization of these derivatives might help in the development of therapeutic agents for the treatment of alopecia. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
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