Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 23, Issue 10, Pages 3023-3027Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.03.020
Keywords
Ostreopsis cf. ovata; Cytotoxic compound; Ostreol A; 20 NMR; Structure determination
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Funding
- National Research Foundation/MEST [NRF-C1ABA001-2010-0020702, NRF-2012R1A2A2A0 1010987]
- KIMST/MLTM
- Kunsan National University
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Ostreol A was isolated from cultures of the epiphytic dinoflagellate Ostreopsis cf. ovata from the coastal waters of Jeju Island, Korea. The compound, a non-palytoxin derivative, has a polyhydroxy chain ending with the primary amino group and contains an amide bond, along with two tetrahydropyran rings in the chain. Its chemical structure was elucidated by nuclear magnetic resonance (NMR) spectroscopy methods and confirmed by mass analysis. The compound exhibited significant cytotoxicity in the brine shrimp lethality test at a concentration of 0.9 mu g/mL. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
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