Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 23, Issue 13, Pages 3723-3727Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.05.013
Keywords
Nonsymmetrical aromatic disulfides; Acetohydroxyacid synthase; Branched-chain amino acids; Enzyme inhibition; Herbicidal activity
Categories
Funding
- Natural Science Foundation of China [21272128]
- National Basic Research Project of China [2010CB126103]
- National Key Technology Research and Development Program [2011BAE06B05-3]
Ask authors/readers for more resources
46 Novel nonsymmetrical aromatic disulfides containing [1,3,4] thiadiazole or [1,3,4] oxadiazole groups were synthesized and their biological activities were evaluated as inhibitors of acetohydroxyacid synthase (AHAS, EC 2.2.1.6). Besides their strong in vitro inhibition against plant AHAS, compounds 3e and 3f also display 80-100% post-emergence herbicidal activities in greenhouse bioassay at 1500 g/ha dosage. The assay of exogenous branched-chain amino acids supplementation on rape root growth of 3e suggests that the herbicidal activity has relationship with AHAS inhibition. (C) 2013 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
