Journal
FOOD AND AGRICULTURAL IMMUNOLOGY
Volume 31, Issue 1, Pages 937-949Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09540105.2020.1788516
Keywords
Campylobacter; lactobacillus; NLRP3 inflammasome; chicken
Funding
- Grant Agency for Science of Slovak Republic [VEGA 1/0112/18]
- Slovak Research and Developmental Agency [APVV-15-0165]
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The aim of this study was to evaluate the influence ofLactobacillus reuteriB1/1 on the local intestinal immune response in the cecum of chickens experimentally infected byC. jejuniCCM6189. Day-old chicken were divided into four groups: control (C),L. reuteriB1/1 (LR),C. jejuniCCM6189 (CJ), and combinedL. reuteriB1/1 + C. jejuniCCM6189 (LRCJ). Cecal samples were collected during necropsy 12, 24, 48 hours after infection byC. jejuni(relative expression of NLRP3, caspase-1, interleukins, TLR4) and 4 as well as 7 day post infection (relative percentage of CD4+, CD8+, IgM).L. reuteriB1/1 significantly stimulated gene expression of NLRP3 inflammasome and other selected molecules, thereby increasing the capacity of the immune system to react more effectively to the infection ofC. jejuniin chicken. In addition, an increase of IgM and the percentage of CD8+ influenced byL. reuteriwas observed.
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