Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 23, Issue 12, Pages 3667-3672Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.12.071
Keywords
Coumarin; Benzimidazole; Hybrids; Anticancer agents; Molecular docking
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Funding
- Council of Scientific and Industrial Research [02(0034)/11/EMR-II]
- Department of Science and Technology, New Delhi [SR/FT/CS-40/2010]
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A series of novel coumarin-benzimidazole hybrids, 3-(1H-benzo[d]imidazol-2-yl)-7-(substituted amino)-2H-chromen-2-one derivatives of biological interest were synthesized. Six out of the newly synthesized compounds were screened for in vitro antitumor activity against preliminary 60 tumor cell lines panel assay. A significant inhibition for cancer cells was observed with compound 8 (more than 50% inhibition) compared with other compounds and active known drug 5-fluorouracil (in some cell lines) as positive control. Compound 8 displayed appreciable anticancer activities against leukemia, colon cancer and breast cancer cell lines. (C) 2013 Elsevier Ltd. All rights reserved.
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