Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 23, Issue 13, Pages 3806-3809Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.04.073
Keywords
Dioscorea nipponica; Dioscoreaceae; Diarylheptanoids; Nitric oxide; Anti-neuroinflammation
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Funding
- Global Leading Technology Program of the Office of Strategic R&D Planning (OSP)
- Ministry of Knowledge Economy, Republic of Korea [10039303]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10039303] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In a continuing search for bioactive constituents from Dioscoreaceae medicinal plants, two new cyclic diarylheptanoids, diosniponol A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of Dioscorea nipponica. The structures of these new compounds were determined by spectroscopic analyses, including extensive two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and optical rotation. All isolated compounds 1-12 were evaluated for their effects on nitric oxide (NO) production in murine microglia cell line BV-2. Compounds 8 and 11 showed potent inhibitory activities on NO production (IC50 13.36 and 14.36 mu M, respectively) without cell toxicity in lipopolysaccharide-activated BV-2 cells. (C) 2013 Elsevier Ltd. All rights reserved.
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