Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 23, Issue 13, Pages 3896-3900Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.04.064
Keywords
Harrisonia perforata; Rearranged limonoid; Chromone; Anti-inflammatory
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Funding
- 90th Anniversary of Chulalongkorn University Fund (Ratchadaphiseksomphot Endownment Fund)
- Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission [AS613A]
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Two new rearranged limonoids, harperforatin (1) and harperfolide (2), and a new chromone, harperamone (3), were isolated from fruits and roots of Harrisonia perforata, together with eight known compounds. Their structures were elucidated on the basis of spectroscopic data. Harperfolide (2) exhibited potent anti-inflammatory activity by suppressing nitric oxide (NO) production from activated macrophages with IC50 value of 6.51 mu M. Furthermore, its effect is mediated by reduction of iNOS protein expression, attributable to the inhibitory action of LPS-induced NO production. (c) 2013 Elsevier Ltd. All rights reserved.
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