Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 23, Issue 13, Pages 3810-3813Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.04.076
Keywords
Metagenome; Marine sponge; Discodermia calyx; Indole-porphyrin hybrid; Escherichia coli
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- National Natural Science Foundation of China [21202033]
- Natural Science Foundation of Hebei Province [C2012201047]
- Grants-in-Aid for Scientific Research [13J10253, 25560399, 25108705] Funding Source: KAKEN
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New indole-porphyrin hybrid molecules were isolated from Escherichia coli harboring metagenomic DNA from the Japanese marine sponge Discodermia calyx. The indole was appended to the reactive vinyl substituent of the harderoporphyrin chromophore, encoded by the insert DNA. Thus, the chimeric pathway between the heterologously expressed porphyrins and the endogenous indole generated new indole-conjugated chiral porphyrins in E. coli. (c) 2013 Elsevier Ltd. All rights reserved.
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