4.5 Article

Novel Hepatitis C virus replicon inhibitors: Synthesis and structure-activity relationships of fused pyrimidine derivatives

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 6, Pages 2212-2215

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.01.096

Keywords

Hepatitis C; Replicon inhibitors; Pyrido[2,3-d]pyrimidines; Pyrimido[4,5-d]pyrimidines

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The synthesis of several pyrido[2,3-d] pyrimidine and pyrimido[4,5-d] pyrimidine analogs is described with one such analog possessing subnanomolar potency in both genotype 1a and 1b cell culture HCV replicon assays. (C) 2012 Elsevier Ltd. All rights reserved.

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