Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 6, Pages 2212-2215Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.01.096
Keywords
Hepatitis C; Replicon inhibitors; Pyrido[2,3-d]pyrimidines; Pyrimido[4,5-d]pyrimidines
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The synthesis of several pyrido[2,3-d] pyrimidine and pyrimido[4,5-d] pyrimidine analogs is described with one such analog possessing subnanomolar potency in both genotype 1a and 1b cell culture HCV replicon assays. (C) 2012 Elsevier Ltd. All rights reserved.
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