Journal
ADIPOCYTE
Volume 9, Issue 1, Pages 212-222Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21623945.2020.1760674
Keywords
Toll-like receptors; inflammation; adipose tissue macrophages; adipogenesis; ear mesenchymal stem cells; bone marrow derived dendritic cells; lipopolysaccharide; saturated fatty acids; cytokines
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Funding
- National Institute of Diabetes and Digestive and Kidney Diseases [K08DK101755]
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In obesity, high levels of saturated fatty acids (SFAs) contribute to adipose tissue inflammation and dysfunction. Obesity-induced macrophage infiltration leads to insulin resistance, but the adipocyte itself may play a role in generating the inflammatory milieu. Given our recent findings of the role of TLR4 in myeloid biasing in obesity, we next investigated the role of TLR4 in adipocyte generated inflammatory responses to SFAs and lipopolysaccharides. We used WT and Tlr4(-/-) ear mesenchymal stem cell derived adipocytes (EMSC Ad) and bone marrow dendritic cells (BMDCs) to evaluate cell specific responses. Our work demonstrates a role for TLR4 in adipocyte- immune cell crosstalk and that SFA derived metabolites from adipocytes may induce proinflammatory stimulation of immune cells in a TLR4 independent manner.
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