Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 12, Pages 4100-4102Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.04.069
Keywords
Matrine derivative; Synthesis; Anti-tumor activity
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Funding
- Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards (Guangxi Institute of Traditional Medical and Pharmaceutical Sciences) [guizhongz-hongkai 0802]
- Guangxi Natural Science Foundation [2010GX NSFD013040]
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Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine. (C) 2012 Elsevier Ltd. All rights reserved.
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