Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 19, Pages 6085-6088Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.08.038
Keywords
Structure-activity relationship; Derivative; Ferulic acid; Caffeic acid; Anticancer
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Funding
- National Key Technology RD Program [2008BAI51B01]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20113237110010]
- Key Research Project in Basic Science of Jiangsu College and University [06KJA36022, 07KJA36024]
- National S. & T. Supporting Program in Chinese Medicine for the 11th Five-Year Plan [2006BAI11B08-01]
- Program for New Century Excellent Talents by the Ministry of Education [NCET-09-0163]
- Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education
- Priority Academic Program Development of Jiangsu Higher Education Institutions [ysxk-2010]
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The anticancer activities of alkyl esters and NO-donors of ferulic acid (FA) and caffeic acid (CA) were assessed by a high-throughout screening (HTS) method, and the structure-activity relationships were described. CA alkyl esters had better anticancer activities than FA alkyl esters with the same alkyl sub-stituent. Mono-nitrates and phenylfuroxan nitrates were more potent than the dual nitrates. Phenylsulfonylfuroxan nitrates of FA, especially compounds 8b-8d, exhibited more potent activities in anticancer. (C) 2012 Elsevier Ltd. All rights reserved.
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