Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 15, Pages 5059-5062Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.06.006
Keywords
Coprinus plicatilis; Basidiomycete; Guanacastepene; Diterpenoid; Cytotoxic activity
Categories
Funding
- 973 Program [2010CB833802, 2012CB721000]
- National Science Fund for Distinguished Young Scholars [30325044]
- Chinese Ministry of Education [306010]
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Four new guanacastane-type diterpenoids (1-4), together with the known compound, guanacastepene E (5), were isolated from a basidiomycete of the macro-fungi, Coprinus plicatilis 82. Their structures were elucidated on the basis of extensive spectroscopic analyses, including FT-ICR-MS, UV, IR and 1D and 2D NMR experiments. The in vitro cytotoxic activities of all compounds against the human cancer cell lines HepG2, HeLa, MDA-MB-231, BGC-823, HCT 116, and U2OS were evaluated, only compound 1 exhibited significant cytotoxicities with IC50 values ranging from 1.2 to 6.0 mu M. (C) 2012 Elsevier Ltd. All rights reserved.
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