Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 4, Pages 1731-1733Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.12.093
Keywords
Hybrid liposomes; Phosphatidylcholine; Cancer; Caveolae
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [24656509, 22134005, 20107007, 23590667, 23659664] Funding Source: KAKEN
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We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1 h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis. (C) 2011 Elsevier Ltd. All rights reserved.
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