Journal
CURRENT OPINION IN BIOMEDICAL ENGINEERING
Volume 13, Issue -, Pages 76-83Publisher
ELSEVIER
DOI: 10.1016/j.cobme.2019.12.006
Keywords
Lipid-oligonucleotide conjugate; DNA; Cell membrane modification; Membrane analysis; Cell regulation
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Funding
- NIH [R35GM133507]
- UMass Amherst
- IALS M2M seed grant
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Cell membrane modification is important for tissue engineering, cell-based therapies, and cell biology studies. Recently, oligonucleotides have attracted considerable attention to remodel and functionalize live cell membranes. In particular, a type of amphiphilic lipid-oligonucleotide conjugates have been rationally designed and synthesized for this purpose. These conjugates have enabled a rapid, straightforward, and efficient cell membrane modification. Taking advantage of highly precise and programmable self-assembly of DNAs and RNAs, lipid-oligonucleotide conjugates have been used for membrane bioanalysis, therapeutics, building artificial membrane structures, and regulating cell-surface and cell-cell interactions. In this review, we have summarized the current knowledge in the design, synthesis, and regulating membrane properties of lipid-oligonucleotide conjugates. In addition, their state-of-the-art applications in cell membrane engineering and bioanalysis have been illustrated.
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