Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 6, Pages 2209-2211Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.01.102
Keywords
Enterovirus 71; Geraniin; Drug; Mouse model
Categories
Funding
- National Basic Research Program of China [973 Program] [2011CB504903]
- National Science and Technology Major Projects [2011ZX09307-302-03]
- Basic Research Universities Special Fund Operations [DWS201107]
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Human enterovirus 71 infection causes hand, foot and mouth disease in children under 6 years of age and has caused mortalities in large-scale outbreaks in the Asia-Pacific region. No effective vaccine or antiviral drugs currently exist against enterovirus 71 in the clinic. In this study, we investigated the antiviral effect of geraniin on enterovirus 71 both in vitro and in vivo. The results showed that geraniin effectively inhibited virus replication in rhabdomyosarcoma cells with an IC50 of 10 mu g/ml. Moreover, geraniin treatment of mice that were challenged with a lethal dose of enterovirus 71 resulted in a reduction of mortality, relieved clinical symptoms, and inhibited virus replication in muscle tissues. The results suggest that geraniin may be used as a potential drug for anti-enterovirus 71. (C) 2012 Elsevier Ltd. All rights reserved.
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