Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 1, Pages 561-563Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.10.077
Keywords
Cell penetration; Polyproline helix; Mitochondrial localization
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Funding
- National Science Foundation [CHE-1012316]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1012316] Funding Source: National Science Foundation
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The development of cell penetrating peptides (CPPs) for the cellular delivery of attached cargo is an area of growing interest. Many CPPs, however, are found trapped within endosomes, thereby limiting their use as drug delivery agents with sub-cellular applications. Herein, we detail the properties of a highly efficient class of CPPs, cationic amphiphilic polyproline helices (CAPHs), that are found localized to the mitochondria by direct transport into cells. (C) 2011 Elsevier Ltd. All rights reserved.
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