Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 24, Pages 7297-7301Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.10.123
Keywords
Hepatitis C virus; Phenotypic high-throughput screening; Infectious cell culture system; 7-Aminopyrazolopyrimidine
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Funding
- National Research foundation of Korea (NRF) grant
- Korea government (MEST) [2011-00244, 2012-00011]
- Gyeonggi-do
- KISTI
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We describe a novel 7-aminopyrazolo[1,5-a]pyrimidine (7-APP) derivative as a potent hepatitis C virus (HCV) inhibitor. A series of 7-APPs was synthesized and evaluated for inhibitory activity against HCV in different cell culture systems. The synthesis and preliminary structure-activity relationship study of 7-APP are reported. (C) 2012 Elsevier Ltd. All rights reserved.
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