Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 14, Pages 4873-4876Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.05.029
Keywords
Iotrochamides A and B; Cinnamoyl-amino acids; Human African trypanosomiasis; Trypanocidal
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Funding
- Drugs for Neglected Disease initiative (DNDi)
- Deutsche Gesellschaft fur Technische Zusammenarbeit GmbH on behalf of the Government of the Federal Republic of Germany
- Australian Research Council (ARC)
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Bioassay-guided isolation of the CH2Cl2/MeOH extract from the Australian sponge Iotrochota sp. resulted in the purification of two new N-cinnamoyl-amino acids, iotrochamides A (1) and B (2). The chemical structures of 1 and 2 were determined by 1D/2D NMR and MS data analyses. Compounds 1 and 2 were shown to inhibit Trypanosoma brucei brucei with IC50 values of 3.4 and 4.7 mu M, respectively. (C) 2012 Elsevier Ltd. All rights reserved.
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