Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 13, Pages 4314-4317Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.05.016
Keywords
Cytotoxic activity; Hybrid chalcones; Claisen rearrangement; Claisen-Schmidt condensation
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Funding
- CSIR, New Delhi
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A new class of hybrid chalcones (17a-l & 18a-l) was synthesized by Claisen-Schmidt condensation. All compounds were characterized by H-1 NMR, IR and mass spectral analysis and tested for their cytotoxic activity against PC-3 (prostate cancer), HT-29 (colon cancer), B-16 (mouse macrophages) and NCI-H460 (lung cancer) cell lines. Three compounds 18i, 18j and 18l (IC50 = 8.4, 7.9 & 5.9 mu M) showed significant activity against PC-3 cell line. (C) 2012 Elsevier Ltd. All rights reserved.
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