Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 4, Pages 1660-1663Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.12.114
Keywords
Zingiberaceae; Alpinia oxyphylla; Sesquiterpenes; Oxyphyllanene A-G; Inhibitory activity against NO production
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Funding
- National Natural Science Foundation of China [30725048, 31000159, 91013002, U1032602]
- National Basic Research Program of China [2009CB522300]
- Chinese Academy of Sciences [KSCX2-YW-R-177]
- National New Drug Innovation Major Project of China [2011ZX09307-002-002]
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Sixteen eudesmane-type sesquiterpenes including seven new compounds oxyphyllanene A-G (1-2 and 5-9) were isolated from the fruits of Alpinia oxyphylla. Among them, compounds 1-2 are novel trinoreudesmane sesquiterpenes, and 5 is a noreudesmane one. Their structures were established by spectroscopic analysis, including 2D-NMR techniques. Inhibitory activity of compounds 3-8 and 10-16 were tested against nitric oxide production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages, and their IC50 values ranged from 9.85 to 13.95 mu g/ml. (C) 2012 Elsevier Ltd. All rights reserved.
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