Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 5, Pages 2114-2118Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.12.095
Keywords
Phoyunbene B; Resveratrol; Cell cycle; Apoptosis
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Funding
- National Natural Science Foundation of China [NSFC-81001664]
- Fundamental Research Funds for the Central Universities [2010121100]
- Xiamen Science and Technology Key program [3502Z20100006]
- Xiamen University
- [2011121058]
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Among the seven natural resveratrol analogs separated and identified from Pholidota yunnanensis R-OLFE, we found phoyunbene B (PYB, trans-3,4'-dihydroxy-2',3',5-trimethoxystilbene) was more effective in inhibiting the growth of HepG2 hepatocellular carcinoma cells than resveratrol. The inhibitory effect of PYB in HepG2 cells was due to its induction of G2/M cell cycle arrest and apoptosis. Induction of G2/M phase cell cycle arrest by PYB was associated with its up-regulation of Cyclin B1, while its induction of apoptosis was accompanied with its down-regulation of Bcl-2 and up-regulation of Bax. Our in vitro invasion/migration assays also showed that PYB could inhibit the invasion of hepatocellular carcinoma cells. (C) 2012 Elsevier Ltd. All rights reserved.
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