Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 22, Issue 23, Pages 7265-7267Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2012.08.115
Keywords
Indole diketopiperazine; Cytotoxicity; Acrostalagmus luteoalbus; Marine fungi; Deep-sea sediment
Categories
Funding
- National Basic Research Program of China [2010CB833800]
- National High Technology Research and Development Program of China [2012AA092104]
- Chinese National Natural Science Fund [40906076, 40906075]
- Innovative Program of The Chinese Academy of Sciences [KSCX2-EW-G-12]
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Two new indole diketopiperazines, namely luteoalbusins A-B (1-2), along with eight known ones (3-10), were isolated from the fungus Acrostalagmus luteoalbus SCSIO F457 originated from deep-sea sediment. Their structures were determined by 1D/2D NMR, MS, and CD data analyses. Each of these compounds was evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 cell lines, and compounds 1-5 showed significant cytotoxicties against all four cancer cell lines. Moreover, new compounds 1 and 2 had more potent cytotoxicity than the other ones and cisplatin. (C) 2012 Published by Elsevier Ltd.
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