Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 2, Pages 690-693Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.12.005
Keywords
Marine-derived fungus; Aspergillus sp.; Gorgonian Dichotella gemmacea; Aspergilone; X-ray analysis; Cytotoxicity; Antifouling activity
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Funding
- National Natural Science Foundation of China [30901879, 40976077, 40776073]
- Higher Education, Ministry of Education of China [20090132110002]
- Science and Technology, Ministry of Science and Technology of China [2007FY210500]
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Two novel benzylazaphilone derivatives with an unprecedented carbon skeleton, aspergilone A (1), and its symmetrical dimer with a unique methylene bridge, aspergilone B (2), have been isolated from the culture broth of a marine-derived fungus Aspergillus sp. from a gorgonian Dichotella gemmacea. Their structures and relative stereochemistries of 1 and 2 were elucidated using a combination of NMR spectroscopy and X-ray crystallography. Compound 1 not only exhibited in vitro selective cytotoxicity but also showed potent antifouling activity. (C) 2010 Elsevier Ltd. All rights reserved.
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