Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 10, Pages 2887-2889Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.03.075
Keywords
Oxazolidinones; Antibacterial
Categories
Funding
- analytical chemistry department of New Drug Discovery Research, Ranbaxy Research Laboratories
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The synthesis and antibacterial activity of 3-(4-([1,2,4] triazolo[4,3-a] pyrimidin-3-yl) phenyl) oxazolidin-2-ones is reported. Thiocarbonyl derivatives were found to be potent inhibitors of Gram-positive pathogens and compound 4l was two to fourfold more potent than Linezolid. (C) 2011 Elsevier Ltd. All rights reserved.
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