Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 1, Pages 524-527Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.10.082
Keywords
3-[Benzimidazo(1,2-c) quinazolin-5-yl]-2Hchromene-2-one and 3[Benzothiadiazoleimidazo(1,2-c) quinazolin5-yl]-2H-chromene-2-ones; Antimicrobial activity; Cellulose sulfuric acid; Microwave irradiation
Categories
Funding
- CSIR [01(2061)/06/EMR-II]
Ask authors/readers for more resources
A series of 3-[benzimidazo(1,2-c) quinazolin-5-yl]-2H-chromene-2-one (6a-6f) and 3-[benzothiadiazoleimidazo( 1,2-c) quinazolin-5-yl]-2H-chromene-2-one derivatives (7a-7f) that incorporate a variety of substituents at the 6-and/or 8-positions of the coumarin moieties have been synthesized utilizing cellulose sulfuric acid as an efficient catalyst under both conventional heating and microwave irradiation procedures. These analogs were evaluated for their antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Streptococcus pyogenes (Gram-positive bacteria), Escherichia Coli, Klebsiella pneumonia, Salmonella typhimurium (Gram-negative bacteria), and Aspergillus niger, Candida albicans, and Aspergillus flavus (Fungi). Two analogs, 6c (a 6,8-dichloro analog, MIC[SA] = 2.5 mu g/mL; MIC[ST] = 2.5 mu g/mL) and 7d (a 6,8-dibromo analog, MIC[ST] = 2.5 mu g/mL) were identified as potent antibacterial agents, and two analogs, 6b (a 6-bromo analog, MIC[AF] = 10 mu g/mL) and 6d (a 6,8-dibromo analog, MIC[AF] = 15 mu g/mL; MIC[CA] = 15 mu g/mL), were identified as potent antifungal agents. Based on the MIC data, analogs 6b, 6c, 6d, and 7d were identified as the most potent antimicrobial agents in the series. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available