Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 10, Pages 2894-2897Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.03.076
Keywords
Marine endophyte; Penicillium chrysogenum; Polyoxygenated steroid; Antifungal activity; Cytotoxic activity
Categories
Funding
- Ministry of Science and Technology [2010CB833802]
- Natural Science Foundation of China [30910103914, 30970293]
- RNAM Center for Marine Microbiology of the Chinese Academy of Sciences [KSCX2-YW-G-073]
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Two new polyoxygenated steroids, namely, penicisteroids A and B (1 and 2), were obtained from the culture extract of Penicillium chrysogenum QEN-24S, an endophytic fungus isolated from an unidentified marine red algal species of the genus Laurencia. In addition, seven known steroids (3-9) were also isolated and identified. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configuration for compound 1 was determined by application of the modified Mosher's method. Penicisteroid A (1), which is a structurally unique steroid having tetrahydroxy and C-16-acetoxy groups, displayed potent antifungal and cytotoxic activity in the preliminary bioassays. Preliminary structure-activity relationships are discussed. (C) 2011 Elsevier Ltd. All rights reserved.
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