Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 17, Pages 5084-5087Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.03.072
Keywords
Aldolase; Rare sugar; Synthesis; FucA
Categories
Funding
- NIH [R01 AI083754, R01 HD061935, R01 GM085267]
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We report herein a one-pot four-enzyme approach for the synthesis of the rare sugars D-psicose, D-sorbose, L-tagatose, and L-fructose with aldolase FucA from a thermophilic source (Thermus thermophilus HB8). Importantly, the cheap starting material DL-GP (DL-glycerol 3-phosphate), was used to significantly reduce the synthetic cost. (c) 2011 Elsevier Ltd. All rights reserved.
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