Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 14, Pages 4220-4223Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.05.072
Keywords
Marine tunicate; Eudistoma glaucus; beta-carboline alkaloids; Eudistomidins H-K
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
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Four new beta-carboline alkaloids, eudistomidins H-K (1-4), were isolated from an Okinawan marine tunicate Eudistoma glaucus and the structures of 1-4 were elucidated on the basis of spectroscopic data. Eudistomidins H (1) and I (2) were new beta-carboline alkaloids possessing a unique fused-tetracyclic ring system consisting of a tetrahydro beta-carboline ring and a hexahydropyrimidine ring. Eudistomidin J (3) showed relatively potent cytotoxicity against murine leukemia cells P388 and L1210, and human epidermoid carcinoma cells KB in vitro. (C) 2011 Elsevier Ltd. All rights reserved.
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