Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 19, Pages 5808-5811Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.07.113
Keywords
Photodynamic therapy (PDT); Photosensitizer; Photocytotoxicity; Temoporfin; Chlorins
Categories
Funding
- Arbeitsgemeinschaft industrieller Forschungsvereinigungen 'Otto-von-Guericke' e. V. (AiF) [KF0579901UL7, KF0249303UL7]
Ask authors/readers for more resources
The synthesis of novel beta-functionalized derivatives of the clinically used photosensitizer Temoporfin has been achieved by nucleophilic addition reactions to a corresponding diketo chlorin. The beta-substituted dihydroxychlorin products exhibit a strong absorption in the red spectral region, a high singlet oxygen quantum yield, and were found to be highly effective in in vitro assays against HT-29 tumor cells. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
