Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 21, Issue 8, Pages 2403-2405Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.02.068
Keywords
Leucine aminopeptidases; Probe; Dual signals; 2-Dicyanomethylene-3-cyano-2,5-dihydrofuran (DCDHF) unit
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Funding
- MEST [2009-0080734, 2010-0001842]
- National Research Foundation of Korea [2009-0080734] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Leucine aminopeptidases (LAPs) are widely distributed in organisms from bacteria to humans, and play crucial roles in cell maintenance and cell growth. Thus, assays for LAP are necessary for measuring its activity and inhibitor potency. In this Letter, we report a small-molecule probe which exhibits colorimetric and fluorogenic changes according to LAP activity. (C) 2011 Elsevier Ltd. All rights reserved.
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